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KMID : 0950020040300020011
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Journal of Health Science & Medical Technology
2004 Volume.30 No. 2 p.11 ~ p.21
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Behavioral pharmacological studies of Acori Graminei Radix on the global cerebral ischemia
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Ham Young-Woon
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Abstract
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Acori Graminei Rhizoma(AR) occupies a particular place in oriental folk medicine as so called tonic remedy. In order to investigate whether ARinfluenced cerebral ischemia induced neuronal and cognitive impairments, we examined the effect of AR on ischemia-induced cell death in the hippocampus, and on the impaired learning and memory in the Morris water maze and passive avoidance in rats. Rats were induced to 10 minutes of forebrain ischemia by four vessel occlusion (4-VO) and reperfused again. AR, when administered to rat at a dose of 100 ㎎/㎏ i.p. water extracts to 0 minutes and 90 minutes after 4-VO, significantly neuroprotective effects by 48.4% in the hippocampus of treated rats. For behavior test, rats were administered saline AR(100 ㎎/㎏ p.o.) daily for two weeks, followed by their training to the tasks. The animals were trained to find a platform in a fixed position during 5 days and then received a 90-s probe trial in which the platform was removed from the pool on the 6thday. In the passive avoidance, animals were one time per day for 1 week. Rats with ischemic insults showed impaired avoidance test. Treatment with AR produced a marked improvenent in escape latency to find the platform in the Morris water maze. AR reduced the ischemia-induced learning disability in the passive avoidance. Consistent with behavioral data, treatments with AR reduced ischemia-induced cell death in the hippocampal CA1 area. These results showed that AR have a protective effect against ischemia-induced neuronal loss and learning and memory damage.
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KEYWORD
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Acori Graminei Rhizoma(AR), 4-vessel occlusion, brain ischemia, neuroprotection, hippocampus
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